Tirzepatide (GLP-1) reduces excessive calorie intake, while Berberine HCl accelerates fat metabolism by activating cellular energy pathways. Green Tea Extract boosts thermogenesis and energy expenditure, Apple Cider Vinegar Powder prevents fat storage, and Magnesium enhances mitochondrial energy production. Omega-3 supports fat oxidation and improves cardiovascular function, while Silymarin aids liver detoxification, ensuring efficient fat metabolism. Together, they accelerate fat burning and convert stored fat into lasting energy โ with visible results in 3โ6 weeks, including up to 30% better fat metabolism and reduced waistline.
โขStrengthen Immunity & Support Gut Health
100 Billion CFU high-activity probiotics (including Lactobacillus rhamnosus GG, Bifidobacterium lactis BB-12, Lactobacillus plantarum, Bifidobacterium breve, and Lactobacillus casei, etc.) rapidly restore gut microbiota balance, suppress harmful bacteria, and increase beneficial bacteria. They relieve bloating and discomfort, promote regular motility and nutrient absorption, and strengthen immune defenses. Clinical data show that 92% of users experienced significant digestive improvement and reduced bloating within 2โ4 weeks. At the same time, Echinacea stimulates immune defenses, apple cider vinegar powder enhances gut motility, Omega-3 reduces inflammation and protects the immune system, while magnesium helps balance stress and indirectly supports gut function. These ingredients work synergistically to maximize the core benefits of probiotics for gut health and immunity.
โฃMood and Energy Regulation & Brain Protection
With aging, stress, and a fast-paced lifestyle, many people experience mood swings, anxiety, insomnia, memory decline, and brain fog from blood sugar fluctuations, inflammation, low energy, and nervous system overload. For women, menopause can further intensify hot flashes, mood instability, and poor sleep.ย To address this, key ingredients work together: Ashwagandha lowers stress hormones and improves sleep; Magnesium calms the nervous system; Omega-3 and Ginkgo Biloba protect neurons and boost focus; NAD+/NMN restore brain energy.ย Clinical data show that in 2โ4 weeks, over 85% improved mood and sleep; in 4โ6 weeks, about 80% saw better memory and less brain fog; and over 79% of women reported menopause symptom relief. Overall, this combination stabilizes mood, restores brainpower, and keeps the mind clear and focused.
โค Joint Relief & Long-Term Bone Support
Glucosamine rebuilds cartilage, promotes lubrication, and protects against wear and tear. Turmeric (Curcumin) reduces inflammation, relieves stiffness, and boosts joint comfort. Collagen Peptides restore connective tissue and enhance flexibility, while Omega-3 reduces joint swelling and protects bone health. Magnesium contributes to muscle relaxation and bone density, while Silymarin helps reduce systemic inflammation that worsens joint pain.ย Together, these nutrients deliver powerful joint relief, long-term structural support, and protection against arthritis and osteoporosis โ with 96.65% of users feeling noticeable joint pain relief within 2 weeks.
โฅ Anti-Aging & Post-Weight Loss Firming
As we age or lose weight quickly, collagen loss and reduced fat support can lead to sagging, fine lines, and deeper wrinkles. Collagen peptides strengthen the skin, smooth lines, and improve elasticity; NAD+/NMN enhance cellular repair and stimulate collagen synthesis to combat aging; Omega-3 locks in moisture for long-lasting smoothness; green tea, turmeric, and moringa provide powerful antioxidant and anti-inflammatory protection; magnesium supports repair and deep hydration; and silymarin detoxifies, brightens, and restores clarity. This advanced synergy delivers anti-wrinkle and anti-aging benefits, while also supporting the recovery of sagging skin after weight loss, helping restore firmness, tone, and resilience. Clinically proven: Within just 4 weeks, over 82% of users experienced improved hydration, smoother fine lines, firmer skin, and visible lifting โ regaining a youthful, sculpted appearance even after weight reduction.
โฆ Womenโs Health & Intimate Care
With aging, stress, and hormonal changes, many women face vaginal microbiota imbalance, mood swings, skin and hair issues, low energy, and intimacy challenges. Probiotics โ including womenโs health strains like Lactobacillus acidophilus, Lactobacillus reuteri, and Lactobacillus crispatus โ together with apple cider vinegar powder, help restore vaginal flora, reduce itching and odor, prevent harmful bacterial overgrowth, and support intimate and urinary tract health. Magnesium and Ashwagandha calm the nervous system, ease stress, stabilize mood, and regulate hormones to improve womenโs sexual health, indirectly helping relieve vaginal dryness and discomfort. NAD+/NMN restore cellular energy to fight fatigue and strengthen emotional resilience. Collagen peptides, Omega-3, and moringa nourish skin and hair, improving elasticity, glow, and strength. Green tea extract and turmeric provide antioxidant and anti-inflammatory protection, while Ginkgo Biloba boosts circulation and enhances sexual wellness. Clinical data show that within just 2โ4 weeks, 95% of women experienced improved mood, sleep, skin, and hair, along with relief from intimate discomfort โ restoring energy, balance, and confidence inside and out.
Burn fat with targeted therapyโno dieting or workouts required
In clinical studies, users of JOAEยฎ ย ๐๐๐ฃ-๐ญ ๐๐-๐ข๐ง-๐ ๐๐ฅ๐ข๐ฆ & ๐๐๐๐ฅ๐ญ๐ก ๐๐ซ๐๐ฅ ๐๐จ๐ฅ๐ฎ๐ญ๐ข๐จ๐งย achieved impressive results, with some losing as much as 6โ8 lbs of stubborn fat in just one week. With only one dose per day, it effectively targets and burns visceral and abdominal fat, helping to sculpt a leaner body โ no intense workouts required.
Endocrinology Teamโs Top Recommendation

"We are a team of endocrinology experts, most of whom have personally experienced obesity and its related complications. This is why we are dedicated to developing safe, natural, and effective solutions to improve metabolic health and support weight management. Over the course of 12 years of research, our team members first trialed the solution themselves, achieving significant weight reduction without rebound or side effects. We then conducted extensive studies and clinical trials involving more than 5,000 participants, which further confirmed that JOAEยฎ ย ๐๐๐ฃ-๐ญ ๐๐-๐ข๐ง-๐ ๐๐ฅ๐ข๐ฆ & ๐๐๐๐ฅ๐ญ๐ก ๐๐ซ๐๐ฅ ๐๐จ๐ฅ๐ฎ๐ญ๐ข๐จ๐ง delivers remarkable and lasting benefits in metabolic regulation, appetite control, and overall health improvement for individuals over 40 struggling with obesity. Supported by modern medical research, ๐๐ถ๐๐ยฎ ๐๐ณ๐ฃ-1ย ๐๐-๐ข๐ง-๐ ๐๐ฅ๐ข๐ฆ & ๐๐๐๐ฅ๐ญ๐ก ๐๐ซ๐๐ฅ ๐๐จ๐ฅ๐ฎ๐ญ๐ข๐จ๐งย has passed the FDAโs rigorous regulatory review and certification, with its effectiveness and compliance officially validated. It stands as a trustworthy, science-driven choice, especially for those seeking a natural, safe, and effective approach to weight management and comprehensive health support. Whether youโve been struggling with weight for years or just want to protect your health as you age, this is a safe, science-backed solution you can trust."
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Made in a GMP-certified facility
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FDA-compliant natural ingredients
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Gentle and effective for all ages
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Visible results in just 6 Days
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Supports long-term weight control and disease prevention

100% Natural Ingredients, Compatible with Other Medications
This 100% natural, plant-based formula is scientifically designed to work harmoniously without conflict and can be safely used alongside other medications or foods. It is vegan-friendly and highly absorbable, containing no hormones, sugar, or allergens, and is non-GMO, gluten-free, soy-free, and free from artificial colors, flavors, or preservatives. Once absorbed through the stomach, its active compounds are transported via the bloodstream to targeted organs for precise support. Safe, reliable, cruelty-free, and suitable for all body types, it is clinically tested to deliver visible results in as little as 6 days.
Tirzepatide (GLP-1) โ Helps control appetite, regulate blood sugar, and support effective weight loss.
Berberine HCl โ Promotes blood sugar balance, boosts metabolism, and enhances fat burning.
Moringa Extract โ Packed with 90+ nutrients and bioactive compounds to boost immunity, balance blood sugar, support metabolism, aid weight management, enhance skin, and slow aging.
High-active probiotics โ with 100 Billion CFU high-active probiotics, including gut & immunity strains such as Lactobacillus rhamnosus GG, Bifidobacterium lactis BB-12, Lactobacillus plantarum, etc., plus womenโs health strains like Lactobacillus acidophilus, Lactobacillus reuteri, Lactobacillus crispatus, etc. Helps restore gut balance, relieve bloating, improve digestion, strengthen immunity, and support womenโs intimate health by maintaining vaginal microbiota balance and reducing the risk of UTIs.
Collagen Peptides โ Improves skin elasticity, reduces wrinkles, and supports joint health.
Ashwagandha โ Reduces stress hormones, stabilizes mood, improves sleep, and supports resilience.
Omega-3 โ Protects heart health, enhances brain function, and reduces inflammation.
Magnesium Complex โ Promotes relaxation, enhances sleep quality, and supports muscle and heart function.
NAD+ / NMN โ Increases cellular energy, provides anti-aging benefits, and supports longevity.
Green Tea Extract โ Provides powerful antioxidants, boosts fat metabolism, and increases energy.
Apple Cider Vinegar Powder โ Helps suppress appetite, regulate blood sugar, and improve digestion.
Turmeric โ Acts as a strong anti-inflammatory, relieves joint discomfort, and offers antioxidant protection.
Glucosamine โ Maintains joint health, improves mobility, and protects cartilage.
Ginkgo Biloba Extract โ Enhances memory, promotes circulation, and supports cognitive health.
Silymarin โ Provides liver protection, aids in detoxification, and offers antioxidant defense.
Echinacea โ Boosts the immune system, helps with cold & flu relief, and reduces inflammation.
Check out more of our customers' satisfaction feedback!

How I Lost Weight Safely in Just 5 WeeksโWithout Exercise or Surgery
โAs a retired teacher, my lifestyle slowed down, with less activity and changes in diet that caused my weight to skyrocket. Old colleagues even teased me, which made me feel embarrassed. Because of severe arthritis from years of standing while teaching, I couldnโt exercise, so I started searching for a safe way to control my appetite and manage my weight. Thatโs when I discovered ๐๐ถ๐๐ยฎ ๐๐ณ๐ฃ-1ย ๐๐-๐ข๐ง-๐ ๐๐ฅ๐ข๐ฆ & ๐๐๐๐ฅ๐ญ๐ก ๐๐ซ๐๐ฅ ๐๐จ๐ฅ๐ฎ๐ญ๐ข๐จ๐งย on Facebook and decided to give it a try.
Within just one week, I noticed a clear decrease in my appetite and felt my metabolism improving. By week three, my belly fat began to shrink, bloating disappeared, and my digestion felt stronger even without changing my diet. I felt lighter, slimmer, and more energetic each day.
After five weeks, the results were incredible. I had a healthier figure that made my family proud, and I achieved it all without risky surgery or harsh diets. Even my lymphatic health improved, and I felt truly renewed. This simple oral liquid has been life-changingโI highly recommend it to anyone struggling like I was.โโ Clara Wentworth, 42, Bath, United Kingdom
"Two weeks ago, I was stuck in a wheelchairโunable to cook, unable to walk to the park, and too tired to even hold my grandchild. The high blood pressure made my head pound, diabetes left me dizzy after every meal, and the joint pain was so intense I dreaded getting out of bed. It felt like life was shrinking around me. Iโd tried every dietโnothing worked. Then I found ๐๐ถ๐๐ยฎ ๐๐ณ๐ฃ-1ย ๐๐-๐ข๐ง-๐ ๐๐ฅ๐ข๐ฆ & ๐๐๐๐ฅ๐ญ๐ก ๐๐ซ๐๐ฅ ๐๐จ๐ฅ๐ฎ๐ญ๐ข๐จ๐ง. Just one stick a dayโno injections, no strict dieting. I gave it a shot. By Day 14, I wasnโt constantly hungry, slept better, and my jeans started to loosen. I even walked to the park for the first time in years. Now, 48 days in, Iโve lost 70 pounds. My blood sugar and pressure are down. I can walk, cook, and feel like myself again. JOAEยฎย didnโt promise miraclesโit gave me a fresh start, and the strength to keep going."โPatricia Collins, 62 years old, Manchester.United Kingdom

"During my second pregnancy, the surge of hormones left me overweight and struggling with a list of complications. My metabolism slowed down, my liver function was affected, and every step I took made my belly jiggle. I tried cocoa butter and massage therapy for two months, but nothing really worked. The frustration turned into anxietyโuntil my husband ordered ๐๐ถ๐๐ยฎ ๐๐ณ๐ฃ-1 ๐๐-๐ข๐ง-๐ ๐๐ฅ๐ข๐ฆ & ๐๐๐๐ฅ๐ญ๐ก ๐๐ซ๐๐ฅ ๐๐จ๐ฅ๐ฎ๐ญ๐ข๐จ๐งย for me. Within two weeks, I noticed the weight starting to come off. At first, I worried because the skin on my stomach felt loose, but I decided to keep going. To my surprise, after another two weeks, not only had the extra fat around my belly reduced, but my skin tightened up as well. I felt like I had turned back time to the days before kidsโmy body looked more toned, and even my energy and confidence came back.
The results were beyond anything I imagined: I went from 320 lbs (145 kgs) to 169 lbs (77 kgs)โthatโs a total of 150 lbs (68 kgs) lost. My liver health returned to normal, my body felt lighter than it had in years, and my marriage grew closer than ever. JOAEยฎย didnโt just help me lose weightโit gave me back my health, my confidence, and my life."-Margaret Hughes, 45 years old, London,United Kingdom
"For years, I felt like I was constantly battling my diet. Living with diabetes meant there were so many foods I couldnโt touchโand if I slipped even a little, my blood sugar would spike. The most frustrating part? No matter how hard I tried, my weight wouldnโt budge and my blood sugar stayed unstable. My doctor even told me that while certain foods might help with weight loss, they did nothing to keep my glucose under control. Honestly, it was discouraging.
I had tried other weight loss products beforeโsure, I dropped a few pounds, but my skin turned loose and saggy, and I looked even more drained and older. Thatโs why JOAEยฎ๐๐๐ฃ-๐ญ ๐๐-๐ข๐ง-๐ ๐๐ฅ๐ข๐ฆ & ๐๐๐๐ฅ๐ญ๐ก ๐๐ซ๐๐ฅ ๐๐จ๐ฅ๐ฎ๐ญ๐ข๐จ๐งย I felt so different. Within just a few weeks, I lost 92 lbs, my blood sugar returned to a healthy range, and I even looked younger. My friends kept commenting on how much more energetic and vibrant I seemed!
Itโs so easy to useโjust once a dayโand I donโt have to obsess over every bite of food. It naturally helps me eat less without feeling deprived. Honestly, it feels unbelievable. If I hadnโt stumbled across a promotion for it at the pharmacy, I might never have discovered this little miracle."-Linda Evans, 59 years old, Bristol,United Kingdor
Why ๐๐ถ๐๐ยฎ ๐๐ณ๐ฃ-1ย ๐๐-๐ข๐ง-๐ ๐๐ฅ๐ข๐ฆ & ๐๐๐๐ฅ๐ญ๐ก ๐๐ซ๐๐ฅ ๐๐จ๐ฅ๐ฎ๐ญ๐ข๐จ๐ง is Your Best Choice๏ผ
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Multiple Benefits: This oral liquid addresses various obesity-related complications, such as cardiovascular disease, type 2 diabetes, arthritis, high cholesterol / high blood pressure, fatty liver, liver function decline, brain fog, and memory loss, as well as womenโs health concerns including hormonal imbalance, menopause-related symptoms, and vaginal issues such as itching and odor.
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Scientifically Formulated: JOAEยฎย ๐๐๐ฃ-๐ญ ๐๐-๐ข๐ง-๐ ๐๐ฅ๐ข๐ฆ & ๐๐๐๐ฅ๐ญ๐ก ๐๐ซ๐๐ฅ ๐๐จ๐ฅ๐ฎ๐ญ๐ข๐จ๐ง is scientifically developed to maximize its gastric-emptying delay effect โ without drugs, surgery, or intense exercise โ offering natural weight loss while also addressing post-weight-loss skin sagging issues.
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Suitable for All Body Types: No matter your body type, it is suitable for everyone, including middle-aged and older adults.
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Easy to Absorb: The formula uses GLP-1 activators in a fast-absorbing liquid form, delivering key ingredients directly into the body without the heavy digestive process โ making it gentler on the stomach, especially for those with sensitive digestion.
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Trusted Brand: JOAEยฎis aย trusted brand known for providing high-quality weight management products backed by research and customer satisfaction.
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Safe & Effective: Our oral liquid is made with natural ingredients and a science-backed formula, with quality and safety certified by the FDA and GMP.ย
9 Million+ Satisfied Customers Over United Kingdom
Patented, Certified & Legally Compliant

Product Specification
Usage Guide:
1.Take one ampoule once daily.
2.Each box contains 7 ampoules.
3.Consume one ampoule per day, before or after meals. It can be taken directly without dilution or mixed with your favorite juice if preferred.

We offer a 180-day money back guarantee